ESPN's Clemson 2025 preseason projections have Tigers favored in all but one big game

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ESPN’s analytics projections have Clemson favored in all but one 2025 regular-season game, but that one will have plenty of eyes in the Palmetto State.

Although Clemson is favored by four points in early lines, ESPN's model gives South Carolina a fairly substantial edge in the home rivalry matchup against Clemson this November: a 60.4% Gamecocks win projection.

The ACC Tigers start the season slightly favored by ESPN over LSU (53.8% win projection).

From there, the next closest projected win comes at home versus SMU (64.3%), followed by the road trip to Louisville (64.5%) and the road trip to Georgia Tech (65.1%).

Conference games not expected to be close include Syracuse (87%) and Florida State (87.1%), with fairly big margins for at UNC (78.1%) and hosting Duke (79.7%).

In preseason ESPN analytics rankings, Clemson is No. 10 with the SP+ and No. 16 with the FPI.

ESPN analytics 2025 Clemson schedule projections

LSU - 53.8% Clemson
Troy - 93.9% Clemson
@Georgia Tech - 65.1% Clemson
Syracuse - 87% Clemson
@UNC - 78.1% Clemson
@Boston College - 73.4% Clemson
SMU - 64.3% Clemson
Duke - 79.7% Clemson
Florida State - 87.1% Clemson
@Louisville - 64.5% Clemson
Furman - 99% Clemson
@South Carolina - 60.4% South Carolina

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